2020-12-17

AbbVie has submitted an application to the Food and Drug Administration (FDA) for review of upadacitinib in the treatment of active psoriatic arthritis (PsA) in adults.

The inflammation and stiffness that The pain and stiff joints caused by arthritis can make it difficult to enjoy everyday activities. Taking an over-the-counter pain reliever like Aleve can get you back to feeling like yourself without letting arthritis keep you on the sideli Psoriatic arthritis is an inflammatory type of arthritis that primarily affects the skin and joints. Arthritis Types Think you may have arthritis? Learn about the four most common warning signs.

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The Janus kinase inhibitor upadacitinib is a potential treatment for psoriatic arthritis. The efficacy and safety of upadacitinib as compared with adalimumab, a tumor necrosis factor α inhibitor, 2021-03-01 2021-04-01 In patients with psoriatic arthritis refractory or intolerant to biologic disease-modifying antirheumatic drugs (DMARDs), upadacitinib (Abbvie; Rinvoq) 15 mg and 30 mg once per day was more effective than placebo over 24 weeks in improving signs and symptoms of psoriatic arthritis, according to a study published in Annals of the Rheumatic Diseases. 1 Background/Purpose: Upadacitinib (UPA) has demonstrated efficacy for the treatment of AS in patients (pts) who were NSAID inadequate responders (IR). 1 Pts with psoriatic arthritis (PsA) and axial involvment often exhibit greater disease activity and quality of life impairments compared with those without axial involvment.

Upadacitinib is a DMARD used to treat inflammatory types of arthritis, such as rheumatoid arthritis (RA).

The team randomized patients with active psoriatic arthritis—defined as > 3 swollen and > 3 tender joints—active or historical psoriasis, and on < 2 non-biologic DMARDs. Patients either received once daily upadacitinib 15 mg, upadacitinib 30 mg, adalimumab 40 mg every other week, or placebo.

If you have this condition or know someone who does, learning more about psoriatic arthritis can he If you or someone you love has been recently diagnosed with psoriatic arthritis, or PsA, then you may have questions about available treatment options. Although there is no cure for PsA, there are plenty of therapeutic options that can help Arthritis is any disease which causes inflammation affecting the joints in the body and can result in varying levels of pain and disability.

“The Janus kinase inhibitor upadacitinib is a potential treatment for psoriatic arthritis. The efficacy and safety of upadacitinib as compared with adalimumab, a tumor necrosis factor α inhibitor, in patients who have an inadequate response to nonbiologic disease-modifying antirheumatic drugs are unclear,” the researchers explained.

A 15 mg or 30 mg once daily dose of upadacitinib has been found to be effective for the treatment of patients with psoriatic arthritis in a 24-week, phase 3 trial. In the trial, 1,704 patients with psoriatic arthritis were administered oral upadacitinib at a dose of 15 mg or 30 mg once daily, placebo, or subcutaneous adalimumab. The percentage of patients with an American College of Reuters Health – 31/03/2021 – In patients with active psoriatic arthritis, daily oral upadacitinib produces significantly more improvement than placebo, but only recipients of the 30 mg dose experienced a significantly better outcome than with standard treatment with adalimumab, according to results from the SELECT-PsA 1 study.

RINVOQ™ (upadacitinib) Meets Primary and All Ranked Secondary Endpoints in Phase 3 Study in Psoriatic Arthritis - Positive top-line study results show that both doses of RINVOQ™ (upadacitinib; 15 mg and 30 mg, once daily) met the primary endpoint of ACR20 response in adult patients with active psoriatic arthritis who had an inadequate response to other bDMARDs at week 12 versus placebo[1] 2020-12-17 · Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2. Philip J Mease, Apinya Lertratanakul, Jaclyn K Anderson, Kim Papp, Filip Van den Bosch, Shigeyoshi Tsuji, Eva Dokoupilova, Mauro Keiserman, Xin Wang, Sheng Zhong, Reva M McCaskill, Patrick Zueger, Aileen L Pangan, William Tillett.
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Phase 3 trials of upadacitinib in atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, Crohn's disease, ulcerative colitis, giant cell arteritis and Takayasu arteritis are ongoing. 1,5-11 Use of upadacitinib in atopic dermatitis is not approved and its safety and efficacy have not been Psoriatic arthritis is a skin condition that affects about 30% of people who have psoriasis, according to the National Psoriasis Foundation. If you have this condition or know someone who does, learning more about psoriatic arthritis can he If you or someone you love has been recently diagnosed with psoriatic arthritis, or PsA, then you may have questions about available treatment options.

Suggested remit: To appraise the clinical and cost effectiveness of upadacitinib within its marketing authorisation for treating active Background: The Janus kinase inhibitor upadacitinib is a potential treatment for psoriatic arthritis. The efficacy and safety of upadacitinib as compared with adalimumab, a tumor necrosis factor α inhibitor, in patients who have an inadequate response to nonbiologic disease-modifying antirheumatic drugs are … A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (SELECT - PsA 1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
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2020-11-12

The efficacy and safety of upadacitinib as compared with adalimumab, a tumor necrosis factor α inhibitor, 2021-03-01 2021-04-01 In patients with psoriatic arthritis refractory or intolerant to biologic disease-modifying antirheumatic drugs (DMARDs), upadacitinib (Abbvie; Rinvoq) 15 mg and 30 mg once per day was more effective than placebo over 24 weeks in improving signs and symptoms of psoriatic arthritis, according to a study published in Annals of the Rheumatic Diseases.